Papers are sorted alphabetically by author.

Abrao, L., Chagas, J. K., Schmid, H. (2010). Periodontal disease and risk for neuropathic foot ulceration in type 2 diabetes. Diabetes Research and Clinical Practice, 90, 34-39.

Aemaimanan, P., Amimanan, P., Taweechaisupapong, S. (2013). Quantification of key periodontal pathogens in insulin-dependent type 2 diabetic and non-diabetic patients with generalized chronic periodontitis. Anaerobe, 22, 64-68.

Albert, D. A., Ward, A., Allweis, P., Graves, D. T., Knowler, W. C., Kunzel, C., Schmidt, A. M. (2012). Diabetes and oral disease: implications for health professionals. Annals of the New York Academy of Sciences, 1255(1),1-15.

Alblowi, J., Tian, C., Siqueira, M. F., Kayal, R. A., McKenzie, E., Behl, Y., Graves, D. T. (2013). Chemokine expression is upregulated in chondrocytes in diabetic fracture healing. Bone, 53, 294-300.

Al-Harthi, L. S., Cullinan, M. P., Leichter, J. W., Thomason, W. M. (2013). The impact of periodontitis on oral health-related quality of life: A review of the evidence from observational studies. Australian Dental Journal, 58, 274-277.

Al-Zahrani, M. S., Bamshmous, S. O., Alhassani, A. A., Al-Sherbini, M. M. (2009). Short-term effects of photodynamic therapy on periodontal status and glycemic control of patients with diabetes. Journal of Periodontology, 80(10), 1568-1573.

Allen, E. M., Matthews, J. B., O’Halloran, D. J., Griffiths, H. R., Chapple, I. L. (2011). Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis. Journal of Clinical Periodontology, 38, 894-901.

American Diabetes Association. (2017). Classification and diagnosis of diabetes. Diabetes Care,40 (Suppl. 1), S14.

Amiri, A. A., Maboudi, A., Bahar, A., Farokhfar, A., Daneshvar, F., Khoshgoeian, H. R., Khalilian, A. (2014). Relationship between Type 2 diabetic retinopathy and periodontal disease in Iranian adults. North American Journal of Medical Sciences, 6, 139-144.

Andriankaja, O. M., Barros, S. P., Moss, K., Panagakos, F. S., DeVizio, W., Beck, J., Offenbacher, S. (2009). Levels of serum interleukin (IL)-6 and gingival crevicular fluid of IL-1beta and prostaglandin E(2) among non-smoking subjects with gingivitis and type 2 diabetes. Journal of Periodontology, 80, 307-316.

Artese, H. P., Foz, A. M., Rabelo Mde, S., Gomes, G. H., Orlandi, M., Suvan, J., Romito, G. A. (2015). Periodontal therapy and systemic inflammation in type 2 diabetes mellitus: A meta-analysis. PLoS ONE, 10, e0128344.

Banu, S., Jabir, N. R., Mohan, R., Manjunath, N. C., Kamal, M. A., Vinod Kumar, K. R., Tabrez, S. (2015). Correlation of toll-like receptor 4, interleukin-transaminases, and uric acid in patients with chronic periodontitis and healthy adults. Journal of Periodontology, 86, 431-439.

Bastos, A. S., Graves, D. T., Loureiro, A. P., Rossa Junior, C., Abdalla, D. S., Faulin Tdo, E., Orrico, S. R. (2012). Lipid peroxidation is associated with the severity of periodontal disease and local inflammatory markers in patients with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 97, E1353-E1362.

Bharti, P., Katagiri, S., Nitta, H., Nagasawa, T., Kobayashi, H., Takeuchi, Y., Izumi, Y. (2013). Periodontal treatment with topical antibiotics improves glycemic control in association with elevated serum adiponectin in patients with type 2 diabetes mellitus. Obesity Research & Clinical Practice, 7, e129-e138.

Boillot, A., Bouchard, P., Moss, K., Offenbacher, S., Czernichow, S. (2015). Periodontitis and retinal microcirculation in the atherosclerosis risk in communities study. Journal of Clinical Periodontology, 42, 342-349.

Borgnakke, W. S., Ylostalo, P. V., Taylor, G. W., Genco, R. J. (2013). Effect of periodontal disease on diabetes: Systematic review of epidemiological observational evidence. Journal of Clinical Periodontology, 40 (Suppl. 14), 135-152.

Botero, J. E., Rodríguez, C., Agudelo-Suárez, A. A. (2016). Periodontal treatment and glycaemic control in patients with diabetes and periodontitis: An umbrella review. Australian Dental Journal, 61, 134-148.

Botero, J. E., Yepes, F. L., Ochoa, S. P., Hincapie, J. P., Roldan, N., Ospina, C. A., Becerra, M. A. (2013). Effects of periodontal non-surgical therapy plus azithromycin on glycemic control in patients with diabetes: A randomized clinical trial. Journal of Periodontal Research, 48(6), 706-712.

Bullon, P., Jaramillo, R., Santos-García, R., Rios-Santos, V., Ramírez, M., Fernández-Palacín, A., Fernández-Riejos, P. (2014). Relation of periodontitis and metabolic syndrome with gestational glucose metabolism disorder. Journal of Periodontology, 85, e1-e8.

Buset, S. L., Walter, C., Friedmann, A., Weiger, R., Borgnakke, W. S., Zitzmann, N. U. (2016). Are periodontal diseases really silent? A systematic review of their effect on quality of life. Journal of Clinical Periodontology, 43, 333-344.

Casarin, R. C., Barbagallo, A., Meulman, T., Santos, V. R., Sallum, E. A., Nociti, F. H., Goncalves, R. B. (2013). Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis. Journal of Periodontal Research, 48, 30-36.

Castrillon, C. A., Hincapie, J. P., Yepes, F. L., Roldan, N., Moreno, S. M., Contreras, A., Botero, J. E. (2015). Occurrence of red complex microorganisms and Aggregatibacter actinomycetemcomitans in patients with diabetes. Journal of Investigative and Clinical Dentistry, 6, 25-31.

Catalfamo, D. L., Britten, T. M., Storch, D. L., Calderon, N. L., Sorenson, H. L., Wallet, S. M. (2013). Hyperglycemia induced and intrinsic alterations in type 2 diabetes-derived osteoclast function. Oral Diseases, 19, 303-312.

Catalfamo, D. L., Calderon, N. L., Harden, S. W., Sorenson, H. L., Neiva, K. G., Wallet, S. M. (2013). Augmented LPS responsiveness in type 1 diabetes-derived osteoclasts. Journal of Cellular Physiology, 228, 349-361.

Chang, J. F., Yeh, J.-C., Chiu, Y. L., Liou, J. C., Hsiung, J. R., Tung, T. H. (2017). Periodontal pocket depth, hyperglycemia, and progression of chronic kidney disease: A population-based longitudinal study. The American Journal of Medicine, 130, 61-69.e1.

Chang, J. S., Tsai, C.-R., Chen, L.-T., Shan, Y.-S. (2016). Investigating the association between periodontal disease and risk of pancreatic cancer. Pancreas, 45, 134-141.

Chang, L. C., Kuo, H. C., Chang, S. F., Chen, H. J., Lee, K. F., Lin, T. H., Chen, C. N. (2013). Regulation of ICAM-1 expression in gingival fibroblasts infected with high-glucose-treated P. gingivalis. Cellular Microbiology, 15, 1722-1734.

Chang, P. C., Chien, L. Y., Chong, L. Y., Kuo, Y. P., Hsiao, J. K. (2013). Glycated matrix up-regulates inflammatory signaling similarly to Porphyromonas gingivalis lipopolysaccharide. Journal of Periodontal Research, 48, 184-193.

Chang, P. C., Tsai, S. C., Chong, L. Y., Kao, M. J. (2014). N-Phenacylthiazolium bromide inhibits the advanced glycation end product (AGE)-AGE receptor axis to modulate experimental periodontitis in rats. Journal of Periodontology, 85, e268-e276.

Chapple, I. L. & Genco, R. (2013). Diabetes and periodontal diseases: Consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. Journal of Clinical Periodontology, 40 (Suppl 14), S106-S112.

Chen, L., Luo, G., Xuan, D., Wei, B., Liu, F., Li, J., Zhang, J. (2012). Effects of non-surgical periodontal treatment on clinical response, serum inflammatory parameters, and metabolic control in patients with type 2 diabetes: A randomized study. Journal of Periodontology, 83, 435-443.

Chen, L., Wei, B., Li, J., Liu, F., Xuan, D., Xie, B., Zhang, J. (2010). Association of periodontal parameters with metabolic level and systemic inflammatory markers in patients with type 2 diabetes. Journal of Periodontology, 81, 364-371.

Chiu, S. Y. H., Lai, H., Yen, A. M. F., Fann, J. C. Y., Chen, L. S., Chen, H. H. (2015). Temporal sequence of the bidirectional relationship between hyperglycemia and periodontal disease: A community-based study of 5,885 Taiwanese aged 35-44 years (KCIS No. 32). Acta Diabetologica, 52, 123-131.

Choi, Y. H., McKeown, R. E., Mayer-Davis, E. J., Liese, A. D., Song, K. B., Merchant, A. T. (2014). Serum C-reactive protein and immunoglobulin G antibodies to periodontal pathogens may be effect modifiers of periodontitis and hyperglycemia. Journal of Periodontology, 85, 1172-1181.

Chokwiriyachit, A., Dasanayake, A. P., Suwannarong, W., Hormdee, D., Sumanonta, G., Prasertchareonsuk, W., Pitiphat, W. (2013). Periodontitis and gestational diabetes mellitus in non-smoking females. Journal of Periodontology, 84, 857-862.

Cianciola, L., Park, B., Bruck, E., Mosovich, L., Genco, R. (1982). Prevalence of periodontal disease in insulin-dependent diabetes mellitus (juvenile diabetes). Journal of the American Dental Association, 104, 653-660.

Corbella, S., Francetti, L., Taschieri, S., De Siena, F., Fabbro, M. D. (2013). Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta-analysis. Journal of Diabetes Investigation, 4(5), 502-509.

Dag, A., Firat, E. T., Arikan, S., Kadiroglu, A. K., Kaplan, A. (2009). The effect of periodontal therapy on serum TNF-alpha and HbA1c levels in type 2 diabetic patients. Australian Dental Journal, 54, 17-22.

D’Aiuto, F., Gable, D., Syed, Z., Allen, Y., Wanyonyi, L., White, S., Gallacher, J. E. (2017). Evidence summary: The relationship between oral diseases and diabetes. British Dental Journal, 222(12), 944-948.

Darré, L., Vergnes, J. N., Gourdy, P., Sixou, M. (2008). Efficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies. Diabetes and Metabolism, 34(5), 497-506.

Dasanayake, A. P., Chhun, N., Tanner, A. C. R., Craig, R. G., Lee, M. J., Moore, A. F., Norman, R. G. (2008). Periodontal pathogens and gestational diabetes mellitus. Journal of Dental Research, 87, 328-333.

Demmer, R., Desvarieux, M., Jacobs, D. R. (2008). Periodontal disease and incident type 2 diabetes. Diabetes Care, 31, 1373-1379.

Demmer, R., Desvraieux, M., Holtfreter, B., Jacobs, D., Wallaschofski, H., Nauck, M., Kocher, T. (2010). Periodontal status and A1c change. Diabetes Care, 33, 1037-1043.

Demmer, R., Jacobs, D. R. Jr, Desvarieux, M. (2008). Periodontal disease and incident type 2 diabetes: Results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study. Diabetes Care, 31, 1373-1379.

Demmer, R., Jacobs, D. R. Jr, Singh, R., Zuk, A., Rosenbaum, M., Papapanou, P. N., Desvarieux, M. (2015). Periodontal bacteria and prediabetes prevalence in ORIGINS: The oral infections, glucose intolerance, and insulin resistance study. Journal of Dental Research, 94, 201S-211S.

Drosatos-Tampakaki, Z., Drosatos, K., Siegelin, Y., Gong, S., Khan, S., Van Dyke, T., Schulze-Spate, U. (2014). Palmitic acid and DGAT1 deficiency enhance osteoclastogenesis, while oleic acid-induced triglyceride formation prevents it. Journal of Bone and Mineral Research, 29, 1183-1195.

Duarte, P. M., Bezerra, J. P., Miranda, T. S., Feres, M., Chambrone, L., Shaddox, L. M. (2014). Local levels of inflammatory mediators in uncontrolled type 2 diabetic subjects with chronic periodontitis. Journal of Clinical Periodontology, 41, 11-18.

Eke, P. I., Wei, L., Thornton-Evans, G. O., Borrell, L. N., Borgnakke, W. S., Dye, B., Genco, R. J. (2016). Risk indicators for periodontitis in US adults: NHANES 2009 to 2012. Journal of Periodontology, 87, 1174-1185.

Emrich, L. J., Shlossman, M., Genco, R. J. (1991). Periodontal disease in non-insulin dependent diabetes mellitus. Journal of Periodontology, 62, 123-131.

Engebretson, S., Chertog, R., Nichols, A., Hey-Hadavi, J., Celenti, R., Grbic, J. (2007). Plasma levels of tumour necrosis factor-alpha in patients with chronic periodontitis and type 2 diabetes. Journal of Clinical Periodontology, 34, 18-24.

Engebretson, S. & Kocher, T. (2013). Evidence that periodontal treatment improves diabetes outcomes: A systematic review and meta-analysis. Journal of Clinical Periodontology, 40 (Suppl 14), S153-S163.

Engebretson, S., Hey-Hadavi, J., Ehrhardt, F. J., Hsu, D., Celenti, R. S., Grbic, J. T., Lamster, I. B. (2004). Gingival crevicular fluid levels of interleukin-1beta and glycemic control in patients with chronic periodontitis and type 2 diabetes. Journal of Periodontology, 75, 1203-1208.

Engebretson, S., Hyman, L. G., Michalowicz, B. S., Schoenfeld, E. R., Gelato, M. C., Hou, W., Tsai, M. Y. (2013). The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: A randomized clinical trial. JAMA, 310, 2523-2532.

Esteves Lima, R. P., Miranda Cota, L. O., Costa, F. O. (2013). Association between periodontitis and gestational diabetes mellitus: A case-control study. Journal of Periodontology, 84, 1257-1265.

Faggion Jr., C. M., Cullinan, M. P., Atieh, M. (2016). An overview of systematic reviews on the effectiveness of periodontal treatment to improve glycaemic control. Journal of Periodontal Research, 51, 716-725.

Field, C. A., Gidley, M. D., Preshaw, P. M., Jakubovics, N. (2012). Investigation and quantification of key periodontal pathogens in patients with type 2 diabetes. Journal of Periodontal Research, 47, 470-478.

Gaikwad, S. P., Gurav, A. N., Shete, A. R., Desarda, H. M. (2013). Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: A clinical study. Journal of Periodontal & Implant Science, 43(2), 79-86.

García, R. I., Krall, E. A., Vokonas, P. S. (1998). Periodontal disease and mortality from all causes in the VA Dental Longitudinal Study. Annals of Periodontology/The American Academy of Periodontology, 3, 339-349.

Gay, I. C., Tran, D. T., Cavender, A. C., Weltman, R., Chang, J., Luckenbach, E., Tribble, G. D. (2014). The effect of periodontal therapy on glycaemic control in a Hispanic population with type 2 diabetes: A randomized controlled trial. Journal of Clinical Periodontology, 41(7), 673-680.

Gilowski, L., Kondzielnik, P., Wiench, R., Płocica, I., Strojek, K., Krzemiński, T. F. (2012). Efficacy of short-term adjunctive subantimicrobial dose doxycycline in diabetic patients – randomized study. Oral Diseases, 18(8), 763-770.

Gokhale, N. H., Acharya, A. B., Patil, V. S., Trivedi, D. J., Setty, S., Thakur, S. L. (2014). Resistin levels in gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus. Journal of Periodontology, 85, 610-617.

Graziani, P., Gennal, S., Solini, A., Petrini, M. (2017). A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontal disease on diabetes: An update of the review of the EFP-AAP workshop. Journal of Clinical Periodontology

Hasuike, A., Iguchi, S., Suzuki, D., Kawano, E., Sato, S. (2017). Systematic review and assessment of systematic reviews examining the effect of periodontal treatment on glycemic control in patients with diabetes. Medicina Oral, Patología Oral, Cirugía Bucal, 22(2), e167-e176.

Hotamisligil, G. S. (2000). Molecular mechanisms of insulin resistance and the role of the adipocyte. International Journal of Obesity and Related Metabolic Disorders, 24 (Suppl 4), S23-S27.

Huang, X., Yang, X., Ni, J., Xie, B., Liu, Y., Xuan, D., Zhang, J. (2015). Hyperglucose contributes to periodontitis: Involvement of the NLRP3 pathway by engaging the innate immunity of oral gingival epithelium. Journal of Periodontology, 86, 327-335.

Hung, S. L., Lee, N. G., Chang, L. Y., Chen, Y. T., Lai, Y. L. (2014). Stimulatory effects of glucose and Porphyromonas gingivalis lipopolysaccharide on the secretion of inflammatory mediators from human macrophages. Journal of Periodontology, 85, 140-149.

Ide, R., Hoshuyama, T., Wilson, D., Takahashi, K., Higashi, T. (2011). Periodontal disease and incident diabetes: A seven-year study. Journal of Dental Research, 90, 41-46.

Ide, M. & Papapanou, P. N. (2013). Epidemiology of association between maternal periodontal disease and adverse pregnancy outcomes – systematic review. Journal of Clinical Periodontology, 40 (Suppl 1), S181-S194.

International Diabetes Federation. (2017). IDF Diabetes Atlas (8th ed.). Brussels, Belgium. Retrieved from

Islam, S. K. M. A., Seo, M., Lee, Y.-S., Moon, S. S. (2015). Association of periodontitis with insulin resistance, β-cell function, and impaired fasting glucose before onset of diabetes. Endocrine Journal, 62, 981-989.

Janket, S. J., Wightman, A., Baird, A. E., Van Dyke, T. E., Jones, J. A. (2005). Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. Journal of Dental Research, 84(12), 1154-1159.

Javed, F., Al-Daghri, N. M., Wang, H. L., Wang, C. Y., Al-Hezaimi, K. (2014). Short-term effects of non-surgical periodontal treatment on the gingival crevicular fluid cytokine profiles in sites with induced periodontal defects: A study on dogs with and without streptozotocin-induced diabetes. Journal of Periodontology, 85, 1589-1595.

Jepsen, S., Blanco, J., Buchalla, W., Carvalho, J. C., Dietrich, T., Dorfer, C., Machiulskiene, V. (2017). Prevention and control of dental caries and periodontal diseases at individual and population level: Consensus report of group 3 of joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. Journal of Clinical Periodontology, 44 (Suppl. 18), S85-S93.

Jiang, Z. L., Cui, Y. Q., Gao, R., Li, Y., Fu, Z. C., Zhang, B., Guan, C. C. (2013). Study of TNF-alpha, IL-1beta and LPS levels in the gingival crevicular fluid of a rat model of diabetes mellitus and periodontitis. Disease Markers, 34, 295-304.

Jiang, S. Y., Wei, C. C., Shang, T. T., Lian, Q., Wu, C. X., Deng, J. Y. (2012). High glucose induces inflammatory cytokine through protein kinase C-induced toll-like receptor 2 pathway in gingival fibroblasts. Biochemical and Biophysical Research Communications, 427, 666-670.

Jones, J. A., Miller, D. R., Wehler, C. J., Rich, S. E., Krall-Kaye, E. A., McCoy, L. C., Garcia, R. I. (2007). Does periodontal care improve glycemic control? The Department of Veterans Affairs Dental Diabetes Study. Journal of Clinical Periodontology, 34, 46-52.

Kanduluru, S. & Naganandini, S. (2014). Effect of nonsurgical periodontal treatment on clinical response and glycemic control in type 2 diabetic patients with periodontitis: Controlled clinical trial. Journal of Indian Association of Public Health Dentistry, 4, 261-267.

Kardesler, L., Buduneli, N., Cetinkalp, S., Kinane, D. F. (2010). Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. Journal of Periodontology, 81, 24-33.

Kassebaum, N. J., Bernabé, E., Dahiya, M., Bhandari, B., Murray, C. J. L., Marcenes, W. (2014). Global burden of severe periodontitis in 1990-2010: A systematic review and meta-regression. Journal of Dental Research, 93, 1045-1053.

Katagiri, S., Nitta, H., Nagasawa, T., Uchimura, I., Izumiyama, H., Inagaki, K., Chiba, H. (2009). Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease. Diabetes Research and Clinical Practice, 83, 308-315.

Kaur, P. K., Narula, S. C., Rajput, R., Sharma, K. R., Tewari, S. (2015). Periodontal and glycemic effects of nonsurgical periodontal therapy in patients with type 2 diabetes stratified by baseline HbA1c. Journal of Oral Science, 57(3), 201-211.

Khader, Y. S., Al Habashneh, R., Al Malalheh, M., Bataineh, A. (2010). The effect of full-mouth tooth extraction on glycemic control among patients with type 2 diabetes requiring extraction of all remaining teeth: a randomized clinical trial. Journal of Periodontal Research, 45, 741-747.

Khaw, K. T., Wareham, N., Bingham, S., Luben, R., Welch, A., Day, N. (2004). Association of hemoglobin A1c with cardiovascular disease and mortality in adults: The European prospective investigation into cancer in Norfolk. Annals of Internal Medicine, 141, 413-420.

Kim, J. H., Lee, D. E., Choi, S. H., Cha, J. H., Bak, E. J., Yoo, Y. J. (2014). Diabetic characteristics and alveolar bone loss in streptozotocin-and streptozotocin-nicotinamide-treated rats with periodontitis. Journal of Periodontal Research, 49, 792-800.

Kiran, M., Arpak, N., Unsal, E., Erdogan, M. F. (2005). The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus. Journal of Clinical Periodontology, 32, 266-272.

Koromantzos, P. A., Makrilakis, K., Dereka, X., Katsilambros, N., Vrotsos, I. A., Madianos, P. N. (2011). A randomized, controlled trial on the effect of non-surgical periodontal therapy in patients with type 2 diabetes. Part I: Effect on periodontal status and glycaemic control. Journal of Clinical Periodontology, 38, 142-147.

Koromantzos, P. A., Makrilakis, K., Dereka, X., Offenbacher, S., Katsilambros, N., Vrotsos, I. A., Madianos, P. N. (2012). Effect of non-surgical periodontal therapy on C-reactive protein, oxidative stress, and matrix metalloproteinase (MMP)-9 and MMP-2 levels in patients with type 2 diabetes: A randomized controlled study. Journal of Periodontology, 83, 3-10.

Kothiwale, S. V., Kothiwale, V. A., Bhargava, P. V. (2013). Effect of noninvasive periodontal therapy on glycaemic control in type 2 diabetes mellitus patients – a randomized control trial. Diabetes, 62 (Suppl 1).

Kumar, M., Bandyopadhyay, P., Mishra, L., Das, S., Kundu, P. K., Mistry, S. (2015). Effect of periodontal therapy on glycemic control and circulating TNF-α in type 2 diabetic patients. International Journal of Diabetes in Developing Countries, 35(2), 96-102.

Lalla, E., Cheng, B., Lal, S., Tucker, S., Greenberg, E., Goland, R., Lamster, I. B. (2006). Periodontal changes in children and adolescents with diabetes: A case-control study. Diabetes Care, 29, 295-299.

Lalla, E., Lamster, I. B., Feit, M., Huang, L., Spessot, A., Qu, W., Schmidt, A. M. (2000). Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. Journal of Clinical Investigation, 105, 1117-1124.

Li, H., Yang, H., Ding, Y., Aprecio, R., Zhang, W., Wang, Q., Li, Y. (2013). Experimental periodontitis induced by Porphyromonas gingivalis does not alter the onset or severity of diabetes in mice. Journal of Periodontal Research, 48, 582-590.

Li, Q., Chalmers, J., Czernichow, S., Neal, B., Taylor, B. A., Zoungas, S., Batty, G. D. (2010). Oral disease and subsequent cardiovascular disease in people with type 2 diabetes: A prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. Diabetologia, 53, 2320-2327.

Li, Q., Hao, S., Fang, J., Xie, J., Kong, X. H., Yang, J. X. (2015). Effect of nonsurgical periodontal treatment on glycemic control of patients with diabetes: A meta-analysis of randomized controlled trials. Trials, 16(1), 291.

Li, Z., Sha, Y. Q., Zhang, B. X., Zhu, L., Kang, J. (2011). Effect of community periodontal care intervention on periodontal health and glycemic control in type 2 diabetic patients with chronic periodontitis. Beijing Da Xue Xue Bao, 43(2), 285-289.

Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Journal of Clinical Epidemiology, 62, e1-e34.

Liew, A. K., Punnanithinont, N., Lee, Y. C., Yang, J. (2013). Effect of non-surgical periodontal treatment on HbA1c: A meta-analysis of randomized controlled trials. Australian Dental Journal, 58(3), 350-357.

Lin, S.-Y., Lin, C.-L., Liu, J.-H., Wang, I.-K., Hsu, W.-H., Chen, C.-J., Chang, Y.-J. (2014). Association between periodontitis needing surgical treatment and subsequent diabetes risk: A population-based cohort study. Journal of Periodontology, 85, 779-786.

Linden, G. J., Linden, K., Yarnell, J., Evans, A., Kee, F., Patterson, C. C. (2012). All-cause mortality and periodontitis in 60-70-year-old men: A prospective cohort study. Journal of Clinical Periodontology, 39, 940-946.

Lindstrom, J. & Tuomilehto, J. (2003). The diabetes risk score: A practical tool to predict type 2 diabetes risk. Diabetes Care, 26, 725-731.

Liu, J., Wu, Y., Wang, B., Yuan, X., Fang, B. (2013). High levels of glucose induced the caspase-3/PARP signaling pathway, leading to apoptosis in human periodontal ligament fibroblasts. Cell Biochemistry and Biophysics, 66, 229-237.

Llambes, F., Silvestre, F. J., Hernandez-Mijares, A., Guiha, R., Bautista, D., Caffesse, R. (2012). Effect of periodontal disease and non-surgical periodontal treatment on C-reactive protein. Evaluation of type 1 diabetic patients. Medicina Oral, Patologia Oral y Cirugia Bucal, 17, e562-e568.

Löe, H. (1993). Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care, 16, 329-334.

Longo, P., Artese, H., Rabelo, M., Kawamoto, D., Foz, A., Romito, G., Mayer, M. P. A. (2014). Serum levels of inflammatory markers in type 2 diabetes patients with chronic periodontitis. Journal of Applied Oral Science, 57, 1-6.

Madianos, P. N. & Koromantzos, P. A. (2017). An update of the evidence on the potential impact of periodontal therapy on diabetes outcomes. Journal of Clinical Periodontology

Mauri-Obradors, E., Jané-Salas, E., Sabater-Recolons, M. del M., Vinas, M., López-López, J. (2015). Effect of nonsurgical periodontal treatment on glycosylated hemoglobin in diabetic patients: A systematic review. Odontology, 103(3), 301-313.

Makiura, N., Ojima, M., Kou, Y., Furuta, N., Okahashi, N., Shizukuishi, S. Amano, A. (2008). Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment. Oral Microbiology and Immunology, 23, 348-351.

Mealey, B. L. (2006). Periodontal disease and diabetes. A two-way street. Journal of the American Dental Association, 137 (Suppl.), 26S-31S.

Merchant, A. T., Shrestha, D., Chaisson, C., Choi, Y. H., Hazlett, L. J., Zhang, J. (2014). Association between serum antibodies to oral microorganisms and hyperglycemia in adults. Journal of Dental Research, 93, 752-759.

Meyle, J. & Chapple, I. (2015). Molecular aspects of the pathogenesis of periodontitis. Periodontology 2000, 69, 7-17.

Moeintaghavi, A., Arab, H. R., Bozorgnia, Y., Kianoush, K., Alizadeh, M. (2012). Non-surgical periodontal therapy affects metabolic control in diabetics: A randomized controlled clinical trial. Australian Dental Journal, 57, 31-37.

Mohamed, H. G., Idris, S. B., Mustafa, M., Ahmed, M. F., Astrom, A. N., Mustafa, K., Ibrahim, S. O. (2015). Impact of chronic periodontitis on levels of glucoregulatory biomarkers in gingival crevicular fluid of adults with and without type 2 diabetes. PLoS ONE, 10, e0127660.

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ, 339, b2535.

Monami, M., Lamanna, C., Marchionni, N., Mannucci, E. (2008). Comparison of different drugs as add-on treatments to metformin in type 2 diabetes: A meta-analysis. Diabetes Research and Clinical Practice, 79, 196-203.

Morita, I., Inagaki, K., Nakamura, F., Noguchi, T., Matsubara, T., Yoshii, S., Sabbah, W. (2012). Relationship between periodontal status and levels of glycated hemoglobin. Journal of Dental Research, 91, 161-166.

Morita, T., Yamazaki, Y., Mita, A., Takada, K., Seto, M., Nishinoue, N., Maeno, M. (2010). A cohort study on the association between periodontal disease and the development of metabolic syndrome. Journal of Periodontology, 81, 512-519.

Munenaga, Y., The Hiroshima Study Group, Yamashina, T., Tanaka, J., Nishimura, F. (2013). Improvement of glycated hemoglobin in Japanese subjects with type 2 diabetes by resolution of periodontal inflammation using adjunct topical antibiotics: Results from the Hiroshima Study. Diabetes Research and Clinical Practice, 100, 53-60.

Natto, Z. S., Aladmawy, M., Alasqah, M., Papas, A. (2015). Is there a relationship between periodontal disease and causes of death? A cross sectional study. Brazilian Dental Journal, 26, 33-38.

Needleman, I., Nibali, L., Di Iorio, A. (2015). Professional mechanical plaque removal for prevention of periodontal diseases in adults -Systematic review update. Journal of Clinical Periodontology, 42, S12–S35.

Noma, H., Sakamoto, I., Mochizuki, H., Tsukamoto, H., Minamoto, A., Funatsu, H., Mishima, H. K. (2004). Relationship between periodontal disease and diabetic retinopathy. Diabetes Care, 27, 615.

Notsu, M., Yamaguchi, T., Okazaki, K., Tanaka, K., Ogawa, N., Kanazawa, I. Sugimoto, T. (2014). Advanced glycation end product 3 (AGE3) suppresses the mineralization of mouse stromal ST2 cells and human mesenchymal stem cells by increasing TGF-beta expression and secretion. Endocrinology, 155, 2402-2410.

O’Connell, P. A., Taba, M., Nomizo, A., Foss Freitas, M. C., Suaid, F. A., Uyemura, S. A., Grisi, M. F. (2008). Effects of periodontal therapy on glycemic control and inflammatory markers. Journal of Periodontology, 79(5), 774-783.

Ozturk, A., Bilgici, B., Odyakmaz, S., Konas, E. (2012). The relationship of periodontal disease severity to serum and GCF substance P levels in diabetics. Quintessence International, 43, 587-596.

Perayil, J., Suresh, N., Fenol, A., Vyloppillil, R., Bhaskar, A., Menon, S. (2014). Comparison of glycated hemoglobin levels in individuals without diabetes and with and without periodontitis before and after non-surgical periodontal therapy. Journal of Periodontology, 85, 1658-1666.

Polak, D. & Shapira, L. (2017). An update of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. Journal of Clinical Periodontology

Poplawska-Kita, A., Siewko, K., Szpak, P., Krol, B., Telejko, B., Klimiuk, P. A., Szelachowska, M. (2014). Association between type 1 diabetes and periodontal health. Advances in Medical Sciences, 59, 126-131.

Pradeep, A. R., Kalra, N., Priyanka, N., Kumari, M., Khaneja, E., Naik, S. B. (2013). Post-treatment levels of stem cell factor and hs-CRP in serum and crevicular fluid of chronic periodontitis subjects with type 2 diabetes. Journal of Investigative and Clinical Dentistry, 4, 89-93.

Promsudthi, A., Pimapansri, S., Deerochanawong, C., Kanchanavasita, W. (2005). The effect of periodontal therapy on uncontrolled type 2 diabetes mellitus in older subjects. Oral Diseases, 11(5), 293-298.

Raman, R. P., Taiyeb-Ali, T. B., Chan, S. P., Chinna, K., Vaithilingam, R. D. (2014). Effect of nonsurgical periodontal therapy verses oral hygiene instructions on type 2 diabetes subjects with chronic periodontitis: A randomised clinical trial. BMC Oral Health, 14, 79.

Rao Deepika, P. C. & Saxena, R. M. (2013). Comparison of glycosylated hemoglobin levels in severe periodontitis patients and healthy controls: A study in an Indian population. Quintessence International, 44, 319-325.

Reyes-García, R., Rozas-Moreno, P., López-Gallardo, G., García-Martín, A., Varsavsky, M., Avilés-Pérez, M. D., Muñoz-Torres, M. (2013). Serum levels of bone resorption markers are decreased in patients with type 2 diabetes. Acta Diabetologica, 50, 47-52.

Rotter, V., Nagaev, I., Smith, U. (2003). Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. Journal of Biological Chemistry, 278, 45777-45784.

Saito, T., Shimazaki, Y., Kiyohara, Y., Kato, I., Kubo, M., Iida, M., Koga, T. (2004). The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: The Hisayama study. Journal of Dental Research, 83, 485-490.

Sakalauskiene, J., Kubilius, R., Gleiznys, A., Vitkauskiene, A., Ivanauskiene, E., Saferis, V. (2014). Relationship of clinical and microbiological variables in patients with type 1 diabetes mellitus and periodontitis. Medical Science Monitor, 20, 1871-1877. https:/

Sanz, M. & Kornman, K. (2013). Periodontitis and adverse pregnancy outcomes: Consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. Journal of Clinical Periodontology, 40 (Suppl. 14), 164-169.

Saremi, A., Nelson, R. G., Tulloch-Reid, M., Hanson, R. L., Sievers, M. L., Taylor, G. W., Knowler, W. C. (2005). Periodontal disease and mortality in type 2 diabetes. Diabetes Care, 28, 27-32.

Sgolastra, F., Severino, M., Pietropaoli, D., Gatto, R., Monaco, A. (2013). Effectiveness of periodontal treatment to improve metabolic control in patients with chronic periodontitis and type 2 diabetes: A meta-analysis of randomized clinical trials. Journal of Periodontology, 84(7), 958-973.

Shaker, O., Ghallab, N. A., Hamdy, E., Sayed, S. (2013). Inducible nitric oxide synthase (iNOS) in gingival tissues of chronic periodontitis with and without diabetes: Immunohistochemistry and RT-PCR study. Archives of Oral Biology, 58, 1397-1406.

Sharma, P., Dietrich, T., Ferro, C. J., Cockwell, P., Chapple, I. L. C. (2016). Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study. Journal of Clinical Periodontology, 43, 104-113.

Shea, B. J., Grimshaw, J. M., Wells, G. A., Boers, M., Andersson, N., Hamel, C., Bouter, L. M (2007). Development of AMSTAR: A measurement tool to assess the methodological quality of systematic reviews. BMC Medical Research Methodology, 7, 10.

Shikama, Y., Kudo, Y., Ishimaru, N., Funaki, M. (2015). Possible involvement of palmitate in pathogenesis of periodontitis. Journal of Cellular Physiology, 230, 2981-2989.

Shultis, W. A., Weil, E. J., Looker, H. C., Curtis, J. M., Shlossman, M., Genco, R. J., Nelson, R. G. (2007). Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care, 30, 306-311.

Simpson, T. C., Needleman, I., Wild, S. H., Moles, D. R., Mills, E. J. (2010). Treatment of periodontal disease for glycaemic control in people with diabetes. Cochrane Database Systematic Review, CD004714.

Simpson, T. C., Weldon, J. C., Worthington, H. V., Needleman, I., Wild, S. H., Moles, D. R., Iheozor-Ejiofor, Z. (2015). Treatment of periodontal disease for glycaemic control in people with diabetes mellitus. Cochrane Database Systematic Review, 6(11), CD004714.

Singh, S., Kumar, V., Kumar, S., Subbappa, A. (2008). The effect of periodontal therapy on the improvement of glycemic control in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. International Journal of Diabetes in Developing Countries, 28, 38-44.

Sjodin, B., Edblad, E., Sondell, K., Dahlen, G. (2012). Minor manifestations of periodontal diseases in young adults with type 1 diabetes mellitus. Periodontal and microbiological findings. Acta Odontologica Scandinavica, 70, 589-596.

Soboku, K., Kikuchi, T., Fujita, S., Takeda, H., Naruse, K., Matsubara, T., Noguchi, T. (2014). Altered gene expression in gingival tissues and enhanced bone loss in rats with diabetes with experimental periodontitis. Journal of Periodontology, 85, 455-464.

Söder, B., Jin, L. J., Klinge, B., Söder, P.-Ö. (2015). Periodontitis and premature death: A 16-year longitudinal study in a Swedish urban population. Journal of Periodontal Research, 42, 361-366.

Soikkonen, K., Wolf, J., Salo, T., Tilvis, R. (2000). Radiographic periodontal attachment loss as an indicator of death risk in the elderly. Journal of Clinical Periodontology, 27, 87-92.

Song, S. J., Lee, S.-S., Han, K., Park, J.-B. (2016). Periodontitis is associated with diabetic retinopathy in non-obese adults. Endocrine, 56, 82-89.

Southerland, J. H., Moss, K., Taylor, G. W., Beck, J. D., Pankow, J., Gangula, P. R., Offenbacher, S. (2012). Periodontitis and diabetes associations with measures of atherosclerosis and CHD. Atherosclerosis, 222, 196-201.

Srinivasa, T. S., Agrawal, P., Goyal, P., Farista, S., Sowmya, N. K., Deonani, S. (2015). Comparative clinical evaluation of glycosylated hemoglobin level in healthy and chronic periodontitis patients: A chairside diagnostic method. Indian Journal of Dental Research, 26, 504-507.

Stratton, I. M., Adler, A. I., Neil, H. A., Matthews, D. R., Manley, S. E., Cull, C. A., Holman, R. R. (2000). Association of glycaemia with microvascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. BMJ, 321, 405-412.

Sun, Q. Y., Feng, M., Zhang, M. Z., Zhang, Y. Q., Cao, M. F., Bian, L. X., Song, K. L. (2014). Effects of periodontal treatment on glycemic control in type 2 diabetic patients: A meta-analysis of randomized controlled trials. Chinese Journal of Physiology, 57(6), 305-314.

Sun, W. L., Chen, L. L., Zhang, S. Z., Wu, Y. M., Ren, Y. Z., Qin, G. M. (2011). Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis. Internal Medicine, 50, 1569-1574.

Takeda, M., Ojima, M., Yoshioka, H., Inaba, H., Kogo, M., Shizukuishi, S., Amano, A. (2006). Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients. Journal of Periodontology, 77, 15-20.

Taylor, G. W. (2001). Bidirectional interrelationships between diabetes and periodontal diseases: An epidemiologic perspective. Annals of Periodontology/American Academy of Periodontology, 6, 99-112.

Taylor, G. W., Burt, B. A., Becker, M. P., Genco, R. J., Shlossman, M., Knowler, W. C., Pettitt, D. J. (1996). Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. Journal of Periodontology, 67, 1085-1093.

Taylor, J. J., Preshaw, P. M., Lalla, E. (2013). A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. Journal of Clinical Periodontology, 40 (Suppl 14), S113-S134.

Teeuw, W. J., Gerdes, V. E., Loos, B. G. (2010). Effect of periodontal treatment on glycemic control of diabetic patients: A systematic review and meta-analysis. Diabetes Care, 33, 421-427.

Telgi, R. L., Tandon, V., Tangade, P. S., Tirth, A., Kumar, S., Yadav, V. (2013). Efficacy of nonsurgical periodontal therapy on glycaemic control in type II diabetic patients: A randomized controlled clinical trial. Journal of Periodontal & Implant Science, 43, 177-182.

Teeuw, W. J., Gerdes, V. E., Loos, B. G. (2010). Effect of periodontal treatment on glycaemic control of diabetic patients: a systematic review and meta-analysis. Diabetes Care, 33, 421-427.

Teshome, A. & Yitayeh, A. (2016). The effect of periodontal therapy on glycemic control and fasting plasma glucose level in type 2 diabetic patients: Systematic review and meta-analysis. BMC Oral Health, 17(1), 31.

Thorstensson, H., Kuylenstierna, J., Hugoson, A. (1996). Medical status and complications in relation to periodontal disease experience in insulin-dependent diabetics. Journal of Clinical Periodontology, 23, 194-202.

Tonetti, M. S. & Van Dyke, T. E. (2013). Periodontitis and atherosclerotic cardiovascular disease: Consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. Journal of Clinical Periodontology, 40 (Suppl. 14), 24-29.

Vos, T., Allen, C., Arora, M., Barber, R. M., Bhutta, Z. A., Brown, A., Murray, C. J. L. (2016). Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet, 388, 1545-1602. S0140-6736(16)31678-6

Wang, X., Han, X., Guo, X., Luo, X., Wang, D. (2014). The effect of periodontal treatment on hemoglobina1c levels of diabetic patients: A systematic review and meta-analysis. PLoS ONE, 9(9).

Wang, T., Jen, I., Chou, C., Lei, Y. (2014). Effects of periodontal therapy on metabolic control in patients with type 2 diabetes mellitus and periodontal disease. Medicine, 93B(28), e292.

Wells, G., Shea, B., O’Connell, D., Peterson, J., Welch, V., Losos, M., Tugwell, P. (2011). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [WWW document]. Retrieved from asp

White, D. A., Tsakos, G., Pitts, N. B., Fuller, E., Douglas, G. V., Murray, J. J., Steele, J. G. (2012). Adult Dental Health Survey 2009: Common oral health conditions and their impact on the population. British Dental Journal, 213, 567-572.

Wu, Y., Chen, L., Wei, B., Luo, K., Yan, F. (2015). Effect of non-surgical periodontal treatment on visfatin concentrations in serum and gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus. Journal of Periodontology, 86, 795-800.

Wu, Y., Liu, F., Zhang, X., Shu, L. (2014). Insulin modulates cytokines expression in human periodontal ligament cells. Archives of Oral Biology, 59, 1301-1306.

Wu, Y. Y., Xiao, E., Graves, D. T. (2015). Diabetes mellitus related bone metabolism and periodontal disease. International Journal of Oral Science, 7, 63-72.

Xiong, X., Elkind-Hirsch, K. E., Vastardis, S., Delarosa, R. L., Buekens, P. (2009). Periodontal disease is associated with gestational diabetes mellitus: A case-control study. Journal of Periodontology, 80, 1742-1749.

Xiong, X., Elkind-Hirsch, K. E., Xie, Y., Delarosa, R., Maney, P., Pridjian, G., Buekens, P. (2013). Periodontal disease as a potential risk factor for the development of diabetes in women with a prior history of gestational diabetes mellitus. Journal of Public Health Dentistry, 73, 41-49.

Xu, J., Xiong, M., Huang, B., Chen, H. (2015). Advanced glycation end products upregulate the endoplasmic reticulum stress in human periodontal ligament cells. Journal of Periodontology, 86, 440-447.

Yang, X., Zhang, J., Ni, J., Ouyang, B., Wang, D., Luo, S., Xuan, D. (2014). Toll-like receptor 4-mediated hyper-responsiveness of gingival epithelial cells to lipopolysaccharide in high-glucose environments. Journal of Periodontology, 85, 1620-1628.

Zhang, H. H., Li, C. Z., Shang, S. H., Luo, Z. X. (2013). Scaling and root planing with enhanced root planing on healthcare for type 2 diabetes mellitus: A randomized controlled clinical trial. Journal of Dental Science, 8, 272-280.

Zhou, M., Rong, R., Munro, D., Zhu, C., Gao, X., Zhang, Q., Dong, Q. (2013). Investigation of the effect of type 2 diabetes mellitus on subgingival plaque microbiota by high-throughput 16S rDNA pyrosequencing. PLoS ONE, 8, e61516.

Zizzi, A., Tirabassi, G., Aspriello, S. D., Piemontese, M., Rubini, C., Lucarini, G. (2013). Gingival advanced glycation end-products in diabetes mellitus-associated chronic periodontitis: An immunohistochemical study. Journal of Periodontal Research, 48, 293-301.

You are currently offline. Some pages or content may fail to load.